Angiotensin and endothelin: messengers that couple ventricular stretch to the Na+/H+ exchanger and cardiac hypertrophy.
نویسندگان
چکیده
Changes in intracellular pH (pHi) can produce marked effects on cardiac function, and, therefore, it is important that the cell possess mechanisms by which pHi is regulated, especially after intracellular acidosis associated with myocardial ischemia. The Na/H exchanger (NHE) and the Na/HCO3 symport represent the 2 major pathways by which alkalinization occurs in cardiac cells. The NHE not only regulates pHi but also cell volume and intracellular signaling in response to a variety of stimuli.
منابع مشابه
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عنوان ژورنال:
- Circulation research
دوره 83 8 شماره
صفحات -
تاریخ انتشار 1998